Chemotherapy drugs causes heart damage
Doxorubin, a chemotherapy drug that has been used for 50 years and is still used until to this day are known to destroy tumor cells, as well as damage to the heart tissue, in some patients.
A research team at The University of Texas MD Anderson Cancer Center had found the mechanism of the drug that attacks the heart muscles. This certainly is capable of providing hope that the cancer drug will no longer attack the heart.
“Until now, doxorubin is the most effective drug to use with other cancer drugs, including breast, lung, uterus, or other,” said Edward TH Yeh, chairman of researchers from MD Anderson’s Department of Cardiology.
“However, its use should be limited because these drugs are toxic for the heart. We are very excited because we found the basis molecular of the cause of damage to the heart caused by doxorubin,” he added, as quoted by the Times of India.
Doxorubin binds the two enzymes in its performance, which are TOP2. TOP2 has two forms Top2a which duty is to destroy cancer cells, and Top2b which can damage cells in the heart muscle. The good news is that Top2b performance is not the same for each person.
Researchers are currently developing ways to look at the sensitivity of patients to Top2b. If the development is successful, the researchers could determine the dose of chemotherapy drugs so that cancer patients do not damage their heart muscle.