Scientists are testing a compound called diallyl trisulfide in rats at risk of liver damage caused by blockage of coronary arteries. Treatment is carried out immediately before blood flow is restored showed nearly two-thirds improvement of damaged liver tissue.
Diallyl trisulfide compound produces hydrogen sulfide in low concentrations that is known able to protect liver tissue. Researchers from Emory University School of Medicine in the United converted diallyl trisulfide, compounds of garlic oil, a substance that can produce hydrogen sulfide on the heart.
Generally, gas easily changes and unstable making it difficult to use as a therapeutic tool because it must be injected. Given these findings, then garlic oil can be consumed directly. The doctor may use diallyl trisulfide in many situations as the findings of the researchers on the use of hydrogen sulfide.
According to a professor from Emory University School of Medicine, David Lefer, his team are conducting research on the active drug that produces hydrogen sulphide which can be drunk. “This could prevent us from injecting drugs containing sulfide outside the emergency situation,” he said.
In their study, the researchers shut down the flow of rat coronary artery for 45 minutes, simulate a heart attack, and gave the diallyl trisulphide to the rats shortly before blood flow is restored. The result showed that these compounds can reduce the proportion of damaged heart tissue in the area at risk up to 61 percent, compared with untreated animals.
These findings were presented on Wednesday, November 16th, 2011 at the American Heart Association’s Scientific Sessions in Orlando, Florida. Further research, according to experts, needs to be done to determine the ability of diallyl trisulphide reduce swelling of the heart caused by heart damage.Tagged with: diallyl trisulfide, Garlic, heart cell,