Swelling of Blood Vessels Can be Detected from the Gene

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Health NewsPeople who are at risk of swelling or rupture of blood vessels can now be detected through the genes. 10 percent of people affected by this disease is because they have a specific gene in the aneurysm.

SOX17 genes series can cause a bulge or balloon in the artery wall (aneurysm) in the brain. Aneurysms develop when blood vessels in the brain swells and weaken the arterial wall.

If a person has swelling or rupture of blood vessels, it could lead stroke or death.

Scientists from Yale University have analyzed the entire genetic code or genome of 20,000 volunteers. The result of this discovery can identify and avoid people who has risk of having the deadly condition.

Aneurysms is a swelling in the arterial wall, while the duty of arteries is to carry blood which are rich in oxygen from the heart to other parts of the body.

If the aneurysm expands,  it could rupture and cause severe bleeding, strokes and even death.

Most aneurysm occurred in the aortic, which is the main artery that travels from the heart through the chest and abdomen. But the aneurysm can also occur in arteries in the brain, heart and other body parts.

Aneurysms can develop and become great without any appearing symptoms. If these conditions can be found at an early stage and promptly handled properly, then the rupture of blood vessels could be prevented or stopped. The main treatment for the condition of aneurism is through drugs and surgery.

In their study, scientists found three new genetic variants that can increase the risk of someone getting infected with aneurysm. Certain variants, such as SOX17 could increase the risk of someone affected by this disease.

These findings could lead doctors to perform examinations (screening) to early identify people who are vulnerable or at risk of contracting this disease.

“These findings provide new insights about the causes of intracranial aneurysm and also is an important step to come in the development of diagnostic tests that can identify high-risk people before symptoms appear,” said Professor Murat Gunel, the senior author in this study, as quoted from the Telegraph, Wednesday ( 7/4/2010).

People who have these genetic codes have risk 5-7 times greater in getting aneurysm. Until now estimated at about 500,000 people suffers aneurysm worldwide each year. The results of this study have been published in the Nature Genetics journal.

“These results explain approximately 10 percent of people are genetically at risk of aneurysm. But this also only explains about 10 percent of everything we know, thus a long time is still needed to understand it more deeply,” said Prof. Gunel.

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